Search results for "Biological computation"

Guest Editors' Introduction to the Special Section on Algorithms in Bioinformatics

2008

Probing the operability regime of an engineered ribocomputing unit in terms of dynamic range maintenance with extracellular changes and time

2020

Synthetic biology aims at engineering gene regulatory circuits to end with cells (re)programmed on purpose to implement novel functions or discover natural behaviors. However, one overlooked question is whether the resulting circuits perform as intended in variety of environments or with time. Here, we considered a recently engineered genetic system that allows programming the cell to work as a minimal computer (arithmetic logic unit) in order to analyze its operability regime. This system involves transcriptional and post-transcriptional regulations. In particular, we studied the analog behavior of the system, the effect of physicochemical changes in the environment, the impact on cell gro…